Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and

technical service of APIs and pharmaceutical intermediates. The marketing department is located in

Wuhan. We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province.

The leading products range of the company is antineoplastic, cardiovascular and antibiotics.

With our strong technical force, under the  sustained effort of the whole staff, we have built high

efficient and swift sales system. The company’s sales network covers more than twenties countries

and areas, also we built good and long relations with many big pharmaceutical company worldwide.

Hesperetin is one of the Citrus bioflavonoid. It is solid substance, light-brown crystalline powder, poorly soluble in water. it belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. it is a bioflavonoid and, to be more specific, a flavanone. Hesperidin (a flavonone glycoside) is water-soluble due to the presence of the sugar part in its structure, so on ingestion it releases its aglycone, i.e, Hesperetin. It is found in Citrus fruits.

Pharmacology

It is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. It may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.

Mechanism of Action

It reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.

Application

It has properties of antioxidant,anti-inflammatory, anti-allergic, hypolipidemic,and anticarcinogenic actions. Hesperidin can also act as a vasodilator, which may be useful in Hypertension. 

It is also used in functional food or dietary supplement as its properties. More studyings are in process to enlarge its use in more industries.

It is known to has anti-esterlysis function, it can inhibit tumor from promoting; as 3 gamma – hydroxyl steroidal dehydrogenase inhibit preparation, high activate aspirin, weak aldose reductase inhibitors, promote rat liver cells DNA synthetic in vitro, pick up a certain antibacterial and antiviral activity, can be used as plant growth promoters.   

Availability

Commercial Hesperetin can be obtained by hydrolyzation from Hesperidin (extracted from immature citrus fruit).