4-Acetamidophenol Best Supplier for Paracetamol 103-90-2 CAS NO.103-90-2

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Product Details

Keywords

103-90-2
Paracetamol
Paracetamol supplier

Quick Details

ProName: 4-Acetamidophenol Best Supplier for Pa...
CasNo: 103-90-2
Appearance: White powder
Application: Local anesthetic; Pharmaceutical inter...
DeliveryTime: 7-8 working days
PackAge: 25KG/DRUM
Port: Any port in China
ProductionCapacity: 10000 Kilogram/Month
Purity: 99%
Storage: 2-8°C
Transportation: By air, by sea, by express delivery
LimitNum: 1 Kilogram

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Details

Company Profile:

Year Established: 2009

Major export product: Tacrolimus, UDCA, Fluorometholone, Mifepristone, Finasteride, Fulvestrant

Major application: Pharmaceutical and Chemical raw materials

Product Name:Paracetamol

Synonyms:4-Acetamidophenol

CAS:103-90-2

MF:C8H9NO2

MW:151.16

EINECS:203-157-5

Product Categories:inhibitor;APIs;DMF file is ok to be provided.;Pyridines;PHARMACEUTICALS;Aromatic Phenols;Intermediates & Fine Chemicals;Lipid signaling;Aromatics

Mol File: 103-90-2.mol

The chemiacal name of 4-acetaminophen is N-(4-hydroxy phenyl) acetamide and the trade name is paracetamol belonging to acetanilide antipyretic analgesics. It was first synthesized by Morse in 1878 and first used in clinic by VonMering in 1893. It has become an over the counter drug in the USA since 1955 and our country started production at the end of the 1950’s. 4-acetaminophen is a white crystalline or a crystalline powder in appearance with melting point from 168℃ to 172℃, odorless, slightly bitter taste, freely soluble in hot water or ethanol, dissolved in acetone, practically insoluble in cold water and petroleum ether. It is stable below 45℃ but will be hydrolyzed into p-aminophenol when exposed to humid air, then oxidized further. The color grades gradually from pink to brown then to black, so it should be sealed and stored in a cool and dry place.

4-Acetamidophenol has the antipyretic activity by inhibiting the synthesis of hypothalamic thermoregulation prostaglandins and its strength of antipyretic effect is similar to aspirin. On the other hand, 4-Acetamidophenol can produce analgesic effect by inhibiting the synthesis of prostaglandins in the central nervous system and blocking impulses of nociceptive nerve endings, but weaker than aspirin. Compared with aspirin, 4-Acetamidophenol has minor irritation, few allergic reactions and other advantages. Its antipyretic and analgesic effect is similar to phenacetin, and the use of 4-acetaminophen increases due to limiting or banning using phenacetin in many countries.

In clinical, it is mainly used for fever and headache caused by cold and relieving mild to moderate pain such as joint pain, muscle pain, neuralgia, migraine, dysmenorrhea, cancer pain, postoperative analgesia and so on. It can be used for patients who are allergic to aspirin, intolerant of aspirin, or unsuited for aspirin, such as patients with varicella, hemophilia and other hemorrhagic disease (patients having anticoagulant therapy included), as well as patients with slight peptic ulcer and gastritis. In addition, it also can be used for the synthesis of benorylate and used as asymmetric synthetic intermediates, photographic chemicals and stabilizer of hydrogen peroxide.

Usage:

This product is antipyretic and analgesic whose international nonproprietary name is Paracetamol. It is the most common non anti-inflammatory analgesia-antipyretic drugs without anti inflammatory and anti rheumatism action. Its antipyretic effect is similar to aspirin, but analgesic effect is weak. It is the best of breed of acetanilid drugs. The product is especially suitable for patients who cannot use carboxylic acids drugs. It is used for cold and toothache. Acetaminophen is also used as organic synthesis intermediates, stabilizer of hydrogen peroxide, photographic chemicals.

Dosage:

1. Oral Paracetamol tablets or paracetamol capsules: adults take 300～600mg at a time and 3～4 times a day according to the need. The daily dosage should not be greater than 2g. Defervescence treatment is generally less than 3 days and the administration of pain relief lasts less than 10 days. Children take 10～15mg/kg every 4～ 6 hours. The dosage of children under the age of 12 does not exceed 5 times a day, a five-day course at most. This product should not be taken for a long time.

2. Dispersible tablets: When take tablets, disperse them in warm water dispersion. The commonly used amount of children is 10～15mg/kg every 4～ 6 hours. The dosage of children under the age of 12 does not exceed 5 times a day, a five-day course at most. Children under 3 years old cut back on the amount.

Packing:

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province.

The leading products range of the company is antineoplastic, cardiovascular and antibiotics. With our strong technical force, under the sustained effort of the whole staff, we have built high efficient and swift sales system. The company’s sales network covers more than twenties countries and areas, also we built good and long relations with many big pharmaceutical company worldwide.

HANWAYS CHEMPHARM CO.,LIMITED