Ursodeoxycholic Acid CAS NO.128-13-2
- FOB Price: USD: 1.00-1.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
in-house(1-10)Kilogram
- Product Details
Keywords
- Ursodeoxycholic Acid manufacturer
- 128-13-2
- Ursodeoxycholic Acid supplier
Quick Details
- ProName: Ursodeoxycholic Acid
- CasNo: 128-13-2
- Molecular Formula: C24H39O4
- Appearance: White to beige
- Application: Local anesthetic; Pharmaceutical inter...
- DeliveryTime: Prompt shipment
- PackAge: 25KG/DRUM
- Port: Any China port
- ProductionCapacity: 10000 Kilogram/Year
- Purity: 99%
- Storage: 2-8°C
- Transportation: General cargo transport
- LimitNum: 1 Kilogram
Superiority
Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets.
The founder has decades experience in pharmaceutical industry. We are not just a trading company, but a comprehensive solutions supplier. With our sound knowledge of pharmaceutical business, to integrate resource and adapt to all different demands of markets is our advantage. We are a small but dynamic and energetic company with high efficient and high flexible decision making system.
Our products cover oncology APIs and intermediates, antiviral APIs and intermediates, cardiovascular APIs and intermediates, hormones APIs and intermediates and so on. Cater to the developing of pharmaceutical industry, we focus on the niche and new compounds.
Our business philosophy is customer-oriented, reliability and trustworthy, better service and win-win. We will take every effort to supply quality products to seek mutual development and benefits.
Details
Brief Description
Product name |
Ursodeoxycholic acid |
Synonyms |
3,7-Dihydroxycholan-24-oic acid; 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid; Ursodiol; 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol; (3alpha,5beta,7alpha)-3,7-dihydroxycholan-24-oic acid; (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; (4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; |
MOQ |
25KG |
CAS No. |
128-13-2 |
Appearance |
An almost white powder |
Molecular Formula |
C24H39O4 |
Molecular Weight |
391.5646 |
Assay |
99% |
Application |
Pharma grade or research purpose |
Packing |
As per your request |
Storage |
Preserve in tight, light-resistant containers in a cool place |
Remarks |
NA |
Custom synthesis |
Available |
Supply Ability |
10000kg/month |
Medical use
An incomplete list of the current uses is as follows:
Reduction in gallstone formation, either in patients with gallstones unfit for cholecystectomy, or obese patients undergoing rapid weight loss to prevent gallstone formation.
For the treatment of primary biliary cholangitis (also known as primary biliary cirrhosis, PBC).
To aim to improve bile flow in patients with cystic fibrosis (controversial[5])
In newborn infants with impaired bile flow
After bariatric surgery, to prevent cholelithiasis due to the rapid weight loss with biliary cholesterol oversaturation and also biliary diskinesia secondary to abnormalities in cholecystokinin and biliary enervation.
Meta-analyses have borne out conflicting results on the mortality benefit of UDCA in PBC, however analyses that exclude trials of short duration have demonstrated a survival benefit and are generally considered more clinically relevant. A Cochrane systematic review in 2012 found no significant benefit in reducing mortality, the rate of liver transplantation, pruritus or fatigue. Ursodiol is the only FDA approved drug to treat PBC but many patients do not respond; other treatments are under study.
Ursodiol may be used to treat intrahepatic cholestasis of pregnancy, to relieve the symptoms of itching, to decrease infant mortality rate, and to decrease bile absorption. Ursodiol is not believed to reduce maternal mortality from hemorrhage in such cases.
In children, ursodeoxycholic acid use is not licensed, as its safety and effectiveness have not been established. Evidence is accumulating that ursodeoxycholic acid is ineffective and unsafe in neonatal hepatitis and neonatal cholestasis.
There is insufficient evidence to justify routine use of ursodeoxycholic acid in cystic fibrosis, especially that available data for analysis of long-term outcomes such as death or need for liver transplantation is lacking.
In double the recommended daily dose, ursodeoxycholic acid reduces elevated liver enzyme levels in those with primary sclerosing cholangitis, but its use was associated with an increased risk of serious adverse events (the development of cirrhosis, varices, death or liver transplantation) in patients who received ursodeoxycholic acid compared with those who received placebo. Serious adverse events were more common in the ursodeoxycholic acid group than the placebo group. The risk was 2.1 times greater for death, transplantation, or minimal listing criteria in patients on ursodeoxycholic acid than for those on placebo.
It is concluded that ursodeoxycholic acid use is associated with improved serum liver tests that do not always correlate with improved liver disease status. WHO Drug Information advises against its use in primary sclerosing cholangitis in unapproved doses beyond 13–15 mg/kg/day.
Recent research at the University of Sheffield indicates that Ursodeoxycholic Acid shows promise in the treatment of Alzheimer's Disease.
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