China (Mainland)
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UDCA 128-13-2 CAS NO.128-13-2
- FOB Price: USD: 4.80-5.00 /Metric Ton Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
In-house(1-10)Metric TonIn-house(10-50)Metric Ton
- Product Details
Keywords
- UDCA manufacturer
- 128-13-2
- UDCA seller
Quick Details
- ProName: UDCA 128-13-2
- CasNo: 128-13-2
- Molecular Formula: C24H40O4
- Appearance: White powder
- Application: Blood lipid regulation, anti - atheros...
- DeliveryTime: Prompt shipment
- PackAge: 25KG/DRUM
- Port: Any China port
- ProductionCapacity: 1000 Kilogram/Year
- Purity: 99%
- Storage: Store at +4°C
- Transportation: General cargo transport
- LimitNum: 1 Kilogram
Superiority
We are concentrating on APIs and pharmaceutical intermediates.
With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of UDCA from Wuhan, Hubei, China.
It is made obtainable from us at the most reasonable rate.
Details
Company Profile:
Company name: Hanways ChemPharm Co., Ltd.
Year Establishment: 2009
Location: 18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
Main product:
- API: Antiobesity; Oncology; Antiviral; Cardiovascular; Antibiotics; Antidiabetics and others
- Peptides
- Hormones
- Intermediates
Product Name:UDCA
CAS:128-13-2
MF:C24H40O4
MW:392.57
EINECS:204-879-3
Mol File: 128-13-2.mol
Product Categories:Pharmaceuticals
Use: to increase bile acid secretion, and to change the composition of bile to reduce cholesterol in bile and cholesterol
Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, from the root-word for bear urso, as bear bile contains the substance, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.
Primary bile acids are produced by the liver and stored in the gall bladder. When secreted into the intestine, primary bile acids can be metabolized into secondary bile acids by intestinal bacteria. Primary and secondary bile acids help the body digest fats. Ursodeoxycholic acid helps regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles containing cholesterol. Because of this property, ursodeoxycholic acid is used to treat (cholesterol) gallstones non-surgically. It is also used to relieve itching in pregnancy for some women who suffer obstetric cholestasis.
While some bile acids are known to be colon tumor promoters (e.g. deoxycholic acid), others such as ursodeoxycholic acid are thought to be chemopreventive, perhaps by inducing cellular differentiation and/or cellular senescence in colon epithelial cells.
It is believed to inhibit apoptosis.
Medical uses:
An incomplete list of the current uses is as follows:
Reduction in gallstone formation, either in patients with gallstones unfit for cholecystectomy, or obese patients undergoing rapid weight loss to prevent gallstone formation.
For the treatment of primary biliary cholangitis (also known as primary biliary cirrhosis, PBC).
To aim to improve bile flow in patients with cystic fibrosis (controversial)
In newborn infants with impaired bile flow
After bariatric surgery, to prevent cholelithiasis due to the rapid weight loss with biliary cholesterol oversaturation and also biliary diskinesia secondary to abnormalities in cholecystokinin and biliary enervation.
Dosage:
1. Choleretic: Each 50mg, 150mg daily.
2. Dissolved gallstones: daily 450-600mg (8-10mg / kg), taken 2 times in the morning and evening. When gallstone removal, oral 50mg every night to prevent recurrence.
3. Hepatomegaly, chronic hepatitis: daily 8-13mg / kg, treatment for 6-24 months.
4. Bile reflux gastritis: 1000mg daily, divided into 2 times taking.
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