China (Mainland)
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TUDCA UDCA Tauroursodeoxycholic acid 14605-22-2 CAS NO.14605-22-2
- FOB Price: USD: 4.80-5.00 /Metric Ton Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
In-house(1-10)Metric TonIn-house(10-50)Metric Ton
- Product Details
Keywords
- TUDCA manufacturer
- 14605-22-2
- TUDCA seller
Quick Details
- ProName: TUDCA UDCA Tauroursodeoxycholic acid 1...
- CasNo: 14605-22-2
- Molecular Formula: C26H45NO6S
- Appearance: White powder
- Application: Blood lipid regulation, anti - atheros...
- DeliveryTime: Prompt shipment
- PackAge: 25KG/DRUM
- Port: Any China port
- ProductionCapacity: 1000 Kilogram/Year
- Purity: 99%
- Storage: Store at +4°C
- Transportation: General cargo transport
- LimitNum: 1 Kilogram
Superiority
We are concentrating on APIs and pharmaceutical intermediates.
With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of TUDCA from Wuhan, Hubei, China.
It is made obtainable from us at the most reasonable rate.
Details
Company Profile:
Company name: Hanways ChemPharm Co., Ltd.
Year Establishment: 2009
Location: 18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
Main product:
- API: Antiobesity; Oncology; Antiviral; Cardiovascular; Antibiotics; Antidiabetics and others
- Peptides
- Hormones
- Intermediates
Product Name:TUDCA
CAS:14605-22-2
MF:C26H45NO6S
MW:499.7
Mol File: 14605-22-2.mol
Product Categories:Pharmaceuticals
Usage:Bear bile active ingredients, treatment of gallstones and liver disease
Tauroursodeoxycholic acid, more commonly referred to as TUDCA, is a bile salt that is found natrually occurring in the body. When regular bile salts reach the intestines, they can be metabolized by bacteria into UDCA and then later bound to a taurine molecule to become TUDCA.
TUDCA is a water-soluble bile salt, which is in contrast to regular bile salts possessing both water soluble and fat soluble ends and conferring a detergent effect. This is good for the bile salt's biological purpose (emulsifying fats in the intestines to help with absorption) but when bile acids back up in the liver, a clinical state called cholestasis which occurs when the liver is unhealthy, these bile salts can be damaging to cells by destroying the membranes and signalling for cell death. TUDCA and other water soluble bile salts like UDCA compete with this toxicity and thus indirectly protect cells from death.
Additionally, it seems that TUDCA is able to reduce stress to any cell's Endoplasmic Reticulum; an organelle in cells that serves as a highway from the nucleus out into the cytoplasm, and aids in folding proteins. Through reducing ER stress, TUDCA has been implicated in a wide range of beneficial metabolic effects such as reducing insulin resistance and diabetes, and being a neurological protection agent. However, usages of TUDCA beyond the liver are preliminary whereas usage of TUDCA for helping an already harmed liver is quite reliable as TUDCA is used in clinical settings (hospitals) for treating cholestasis.
Dosage:
10-13mg daily has once been shown to improve liver regenesis rates in a clinically ill population, and may be the lowest estimate of an active oral dose. When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study.
Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.
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